![]() ![]() Cutting both strands of DNA harms the virus more than cutting one strand. The new method uses less memory and thereby it increases the overall speed and efficiency. Thus, a new method has been developed using dynamic programming to fetch the palindromic nucleic acid sequences. Bacteria have evolved to 'disable' bacteria-targeting viruses (bacteriophages) using restriction enzymes that bind to these palindromic sequences. A typical nucleotide palindromic sequence would be TATA (5' to 3') and its complimentary sequence from 3' to 5' would be ATAT. Palindromic sequences are found in abundance in the genome of most organisms. The last reason has been important in the struggle between viruses and bacteria. Palindromic sequences have great significance. Note the first three bases GGA are followed by the complement of those three bases in reverse order: TCC. For example the recognition sequence for BamHI is GGATCC. It is even possible that two enzymes work as a dimer to cut the palindromic sequence, further increasing efficiency. Palindromic sequences are a short run of bases (typically 3 to 5 in length), follow by their complementary bases in reverse order. This means that the enzyme recognizes the sequence no matter from which side the enzyme approaches the DNA.Ī palindromic sequence also increases the chance that both strands of DNA are cut. Several questions are addressed in this work. Results In this work, we tried to revisit this relatively neglected phenomenon. However, our knowledge about their evolutionary origin and their possible importance is incomplete. A palindromic sequence is the same backwards and forwards on both sides (see image below). Importance of Palindromic sequences: Significance of Palindromic sequences: Examples of palindromic sequences: Wrapping up: What is a palindromic sequence Palindrome similar from both directions Or Palindrome reads the same from both sides. It has been previously shown that palindromic sequences are frequently observed in proteins. Luckily! because you don't want a 'pacman' that cuts DNA at random places.ĭNA is double stranded, so it has 'two sides' to which the enzyme can bind. It binds to the DNA only in one specific configuration. Enzymes such as restriction enzymes have to recognize a very specific sequence in order to carry out its task. ![]()
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